Loss of Saltation and Presynaptic Action Potential Failure in Demyelinated Axons
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چکیده
منابع مشابه
Loss of Saltation and Presynaptic Action Potential Failure in Demyelinated Axons
In cortical pyramidal neurons the presynaptic terminals controlling transmitter release are located along unmyelinated axon collaterals, far from the original action potential (AP) initiation site, the axon initial segment (AIS). Once initiated, APs will need to reliably propagate over long distances and regions of geometrical inhomogeneity like branch points (BPs) to rapidly depolarize the pre...
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The prominent symptoms associated with central demyelinating diseases such as multiple sclerosis (MS) are primarily caused by conduction deficits in affected axons. The symptoms may go into remission, but the mechanisms underlying remissions are uncertain. One factor that could be important is the restoration of conduction to affected axons, but it is not known whether demyelinated central axon...
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Transmission of electrical signals in biological systems operates under constraints imposed by thematerials used to build the conducting pathways. The conduction medium in nerves is a membrane-enclosed dilute salt solution rather than a metal wire, for example, as in macroscopic physical systems. Axons have been compared for decades to undersea cables that are surrounded by saltwater.However, t...
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متن کاملSlow sodium-dependent potential oscillations contribute to ectopic firing in mammalian demyelinated axons.
Ectopic action potentials can arise at regions of axonal demyelination, and are believed to contribute to a range of symptoms in patients with demyelinating conditions such as multiple sclerosis. The mechanism(s) by which the ectopic impulses are generated are uncertain. We have previously shown that such ectopic activity can result from inward potassium currents. Paradoxically, the potassium c...
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ژورنال
عنوان ژورنال: Frontiers in Cellular Neuroscience
سال: 2017
ISSN: 1662-5102
DOI: 10.3389/fncel.2017.00045